—— Professional Solutions from Guangzhou Cleanroom Construction Co., Ltd.

In the biopharmaceutical industry, workshop flooring serves not only as the foundation for supporting production equipment and personnel activities but also as a critical factor in ensuring drug production quality. The stringent GMP standards impose extremely high requirements on the cleanliness, corrosion resistance, impact resistance, and ease of cleaning of flooring. Additionally, operational conditions such as humid environments, chemical reagent erosion, frequent sterilization, and heavy equipment traffic make flooring engineering a major challenge restricting long-term stable workshop operations. As a professional service provider with years of expertise in the purification field, Guangzhou Cleanroom Construction Co., Ltd. has developed a full-chain solution integrating material selection, process design, and construction management to help biopharmaceutical enterprises overcome flooring engineering challenges.

I. Analysis of Core Challenges in Biopharmaceutical Workshop Flooring Engineering

(1) Durability Challenges: Performance Tests Under Multiple Operational Conditions

• Risk of Chemical Corrosion: Frequent contact with strong acids (e.g., hydrochloric acid, phosphoric acid), strong alkalis (e.g., sodium hydroxide), and organic solvents (e.g., ethanol, acetone) during production can easily cause surface peeling, discoloration, and cracking in ordinary flooring materials.
• Increased Mechanical Wear: High-frequency operation of forklifts and handling equipment, combined with vibration from equipment foundations, can lead to surface wear, sanding, and even structural cracking of the flooring.
• Impact of Temperature Fluctuations: Temperature variations between high-temperature steam (above 121°C) in sterilization processes and low-temperature storage areas (e.g., cold chain workshops) can cause thermal expansion and contraction in flooring materials, leading to joint delamination.

(2) Cleanliness Pain Points: Hidden Threats to Aseptic Environments

• Crevice Contamination Risks: Joints and expansion gaps in traditional flooring are prone to dust and debris accumulation, creating breeding grounds for microorganisms that are difficult to eliminate through daily cleaning.
• Surface Adsorption Issues: Non-dense material surfaces easily adsorb pharmaceutical liquids and dust, not only affecting cleanliness but also risking cross-contamination.
• Inadequate Sterilization Tolerance: Long-term use of ultraviolet sterilization, ozone disinfection, and chemical disinfectants (e.g., peracetic acid) can accelerate aging of ordinary flooring materials and release harmful substances.

II. Guangzhou Cleanroom Construction’s Full-Process Solutions: Systematic Breakthroughs from Materials to Processes

(1) Precise Material Selection: High-Performance Materials for Stringent Conditions

In response to the unique demands of biopharmaceutical workshops, Guangzhou Cleanroom Construction has curated three core material systems:

• Epoxy Resin Mortar Flooring: Suitable for general production areas (e.g., batching rooms, packaging areas), this system uses high-solid epoxy resin as the base with quartz sand aggregate for enhanced wear resistance. It offers excellent chemical corrosion resistance (withstands pH 2–12 environments) and a seamless surface, supporting static loads of 20–30 tons. Example: An antibody drug production workshop using this material showed no visible wear after 3 years of frequent ethanol disinfection and equipment handling.
• Polyurethane Mortar Flooring: Designed for high-demand areas (e.g., aseptic filling rooms, culture medium preparation areas), this system uses imported polyurethane resin and graded sand. It resists extreme temperatures (-40°C to 130°C), impacts (withstands a 10kg ball drop from 1m), and microbial penetration. Its hydrophobic surface repels liquid penetration and is FDA-certified for pharmaceutical contact safety.
• Vinyl Ester Heavy-Duty Anti-Corrosion Flooring: For highly corrosive environments (e.g., wastewater treatment areas, hazardous waste storage), this system uses vinyl ester resin with glass flake reinforcement, resisting long-term immersion in 98% sulfuric acid and 30% sodium hydroxide, with a service life three times that of ordinary materials.

(2) Process Innovation: Creating "Seamless + Functional" Clean Spaces

• Comprehensive Subfloor Pretreatment: Pre-construction involves shot blasting and grinding to ensure subfloor flatness (≤3mm/3m error) and enhance adhesion via penetrating interface agents, eliminating 空鼓 (hollowing) risks. For retrofits, a unique "crack grouting + carbon fiber reinforcement" process addresses structural defects.
• Gradient Construction Layers:
  • Primer: Penetrating epoxy sealant blocks moisture and contaminants from the subfloor.
  • Mortar Base Coat: 3–5mm quartz sand mortar layer enhances compressive and impact resistance.
  • Top Coat: Customized finishes (matte anti-slip for walkways, mirror-smooth for cleanrooms, or conductive for precision areas) meet functional needs.
• Seamless Design Technology: Continuous troweling eliminates joints, while rounded corners (R≥50mm) and custom waterproof weirs around drains/equipment bases create "zero 死角" (zero dead-angle) clean spaces. A vaccine workshop using this process achieved cleanliness metrics 20% better than GMP standards.

(3) Intelligent Quality Control: Digital Construction for Assurance

BIM modeling pre-plans flooring layouts to simulate equipment loads, drainage slopes, and expansion joint placement. Real-time humidity/temperature sensors (optimal: ≤75% RH, 10–30°C) monitor curing conditions during construction. Post-completion 3D laser scanning verifies flatness and thickness, with data uploaded to a traceable quality management system.

III. Case Study: Flooring Engineering at a Biopharmaceutical Production Base

Project Background

A South China recombinant protein drug production base (including bulk drug, formulation, and logistics areas) required EU GMP and China NMPA compliance. Original flooring failed after 1 year due to bubbling, corrosion, and damage, disrupting production.

Solutions

• Zoned Customization:
  • Bulk Drug Workshop (High Corrosion): 6mm vinyl ester flooring with FRP anti-corrosion skirting.
  • Formulation Workshop (Aseptic Filling): 5mm polyurethane mortar flooring with nano-antibacterial topcoat.
  • Logistics Corridors: 3mm epoxy mortar flooring with anti-slip coating.
• Construction Highlights:
  • Subfloor repair: Cracked areas replaced with C30 steel fiber concrete for enhanced durability.
  • Joint sealing: Elastic sealants filled equipment anchor holes to prevent stress damage.
  • Curing: 7-day closed curing with daily dew point monitoring to prevent moisture-related defects.

Results

After 3 years, the flooring system withstood heavy equipment use, twice-weekly steam sterilization, and frequent chemical cleaning without damage, enabling successful international certification audits.

IV. Guangzhou Cleanroom Construction: Professional Empowerment for Biopharmaceutical Clean Production

As a purification equipment and engineering solutions provider, Guangzhou Cleanroom Construction adheres to a "needs-driven + innovative technology" philosophy, offering full-lifecycle services from site surveys to maintenance. Recognizing that every flooring detail impacts drug safety, we deliver not just standardized products but customized solutions tailored to process requirements, equipment layouts, and regulatory compliance.

In an era of high-quality biopharmaceutical development, Guangzhou Cleanroom Construction is committed to being your trusted partner in creating clean production environments—overcoming engineering challenges and safeguarding the "first inch of production ground" for pharmaceutical quality.